Compile Data Set for Download or QSAR
maximum 50k data
Found 309 Enz. Inhib. hit(s) with BLAST sequence identity > 85%
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50263130((+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-3-yl)-5'-p...)
Affinity DataKi:  0.0210nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50263095((+)-7-Methyl-2-exo-[3'-(2-fluoropyridin-4-yl)-5'-p...)
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50263171((+)-2-(6'-[18F]fluoro-3,3'-bipyridin-5-yl)-7-methy...)
Affinity DataKi:  0.0470nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50263131((+)-7-Methyl-2-exo-[3'-(6-fluoropyridin-2-yl)-5'-p...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]epibatidine from rat alpha6beta2 nAChR expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498034(CHEMBL3329543)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50004108((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498051(CHEMBL3329528)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498045(CHEMBL3329537)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498033(CHEMBL3329540)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498046(CHEMBL3329538)
Affinity DataKi:  55nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86240(Alpha-Conotoxin MII | Gly-L-Cys(1)-L-Cys(2)-L-Ser-...)
Affinity DataKi:  66nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498052(CHEMBL3329546)
Affinity DataKi:  75nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498048(CHEMBL3329541)
Affinity DataKi:  92nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498038(CHEMBL3329542)
Affinity DataKi:  170nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498035(CHEMBL3329530)
Affinity DataKi:  190nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498040(CHEMBL3329533)
Affinity DataKi:  240nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498053(CHEMBL3329545)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50045045(CHEMBL3341965)
Affinity DataKi: >300nMAssay Description:Partial agonist activity at rat alpha6 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498050(CHEMBL3329544)
Affinity DataKi:  310nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498041(CHEMBL3329531)
Affinity DataKi:  350nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498047(CHEMBL3329539)
Affinity DataKi:  490nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498032(CHEMBL3329532)
Affinity DataKi:  580nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498044(CHEMBL3329529)
Affinity DataKi:  610nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498037(CHEMBL3329535)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50498039(CHEMBL3357969)
Affinity DataKi:  2.50E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86241(CAS_23255-54-1 | Dihydro-Beta-erythroidine | NSC_3...)
Affinity DataKi:  2.80E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498049(CHEMBL3329534)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86243(CAS_17360 | MG624 | NSC_17360)
Affinity DataKi:  4.52E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498036(CHEMBL3329527)
Affinity DataKi:  7.20E+3nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM86242(CAS_64645 | NSC_64645 | Tubocurarine,d)
Affinity DataKi:  7.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498043(CHEMBL3329526)
Affinity DataKi:  1.00E+4nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50038416((1,6-trimethyl ammonium)hexane; dibromide | CHEMBL...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Chick)
University of Milan

Curated by PDSP Ki Database
LigandPNGBDBM50060582(1,10-Bis(trimethyl ammonium)decane dibromide | 1,1...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498042(CHEMBL3329525 | EN300-30215)
Affinity DataKi:  2.60E+4nMAssay Description:Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Homo sapiens (Human))
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481208(CHEMBL594330)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50334463(1,3,5-tri-{5-[1-(3-picolinium)]-pent-1-ynyl}benzen...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567433(CHEMBL4869892)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567430(CHEMBL4860756)
Affinity DataIC50:  0.240nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-3(Rattus norvegicus)
Hainan University

Curated by ChEMBL
LigandPNGBDBM50445330(CHEMBL3104243)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of rat alpha6/alpha3beta2beta3 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clamp electroph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Homo sapiens (Human))
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481207(CHEMBL595286)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567432(CHEMBL4876825)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50334472(1,3,5-tris(5-(3,4-dihydroisoquinolin-2(1H)-yl)pent...)
Affinity DataIC50:  0.350nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Homo sapiens (Human))
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481206(CHEMBL595311)
Affinity DataIC50:  0.390nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567431(CHEMBL4878931)
Affinity DataIC50:  0.410nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Rattus norvegicus (Rat))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567433(CHEMBL4869892)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of rat alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6/beta-2(Homo sapiens (Human))
Boise State University

Curated by ChEMBL
LigandPNGBDBM50481209(CHEMBL595047)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of alpha6beta2 nAChRMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50445325(CHEMBL3104238)
Affinity DataIC50:  0.950nMAssay Description:Antagonist activity at human alpha6/alpha3beta2beta3 nAChR expressed in Xenopus oocytes assessed as inhibition of ACh-induced current by voltage clam...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-6(Rattus norvegicus)
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50334464(1,12-bis(3-methyl-5,6-dihydropyridin-1(2H)-yl)dode...)
Affinity DataIC50:  0.950nMAssay Description:Antagonist activity at alpha6 nAChR in rat striatum assessed as inhibition of nicotine-induced [3H]dopamine releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50170585(CHEMBL406906)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha-6-alpha-3-beta-2-beta-3; Range is 0.7-1 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/alpha-6/beta-4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL
LigandPNGBDBM50567427(CHEMBL4872474)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human alpha6/alpha3beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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